Abstract: In order to meet the needs of customers with diversified requirements for the customization of CNC deep hole drilling machines, a rapid design method of CNC deep hole drilling machine based on knowledge reuse was proposed, using rule-based reasoning (RBR) and case-based reasoning (CBR). The hybrid inference technique is used to study the knowledge reuse of CNC deep hole drilling machine. Based on the knowledge reuse theory, according to the design requirements of the CNC deep hole drilling machine structure, a reasonable module division is carried out, and a numerical control deep hole drilling machine model library is established. Using Visual Basic 6.0 to develop SolidWorks 2010, select Access as the system database, develop a rapid design system, and realize the rapid design of CNC deep hole drilling machine.