Abstract: High temperature is the technical bottleneck of grinding hard alloy at present. Compared with the traditional dry grinding condition, the cooling and lubricating method of nanofluid micro lubrication (nmql) is an effective measure to solve the grinding thermal damage. In order to verify the feasibility of grinding cemented carbide under nano-fluid Micro-lubrication condition, a heat transfer model of cemented carbide was established, and the grinding temperature field of cemented carbide was simulated numerically. The surface grinding experiments of cemented carbide (YG8) under different working conditions were carried out. The results show that the grinding temperature (227.2 ℃), Micro-lubrication (MQL) and nano-fluid Micro-lubrication are reduced by 20.42% and 39.48% respectively under dry grinding conditions. The error between numerical simulation temperature and experimental measurement temperature is 6.3%. Based on the macro parameters (specific grinding force, grinding temperature) and micro parameters (grinding wheel surface morphology), the effects of different working conditions on wheel wear were studied. The experimental results further prove that nano-fluid Micro-lubrication is suitable for grinding of cemented carbide.