Abstract: The original configuration is improved by the systematic layout planning method, and hybrid assembly system layout configuration is taken as the object; the. The relationship of operation area, system comprehensive relation and operation area level are calculated with the constraint condition of system material flow, and the improved system layout configuration is presented. The two simulation models of layout configuration are built based on simulation technology. The system performance of the two configurations is compared with the system assembly capacity and utilization ratio. The simulation results show that: the assembly manufacturing capacity of improved system layout configuration is increased significantly with the change of the simulation time, and the utilization trend curve of improved system layout configuration is higher than the original layout configuration with the condition of different simulation time.