Abstract: In order to meet the flexible manufacturing requirement of motor shaft put forward by the enterprise, the load-unload system using industrial robot is designed by the computer virtual simulation technology, including the establishment and layout of equipment models, communication between equipments and off-line programming of robot. The simulation of robot load-unload system in the production process of motor shaft is realized. The simulation results show that the takt time of FML(flexible manufacturing line) can be optimized by changing the TCP(tool centre point) speed. Compared with manual operation, the productivity can be increased by at least 20%. The load-unload system can be used as a test platform to verify the scheme of FML. It is significant to reduce the investment risk of enterprises and improve the design efficiency of engineers.