Abstract: Taking the production line of multi machine tool machining and multi robot operation as the research object, the simulation model of production line with drive is established based on the platform of RobotStudio. Firstly, the design of robot hand, the calibration of tool coordinate, the calibration of workpiece coordinate system and the design of dynamic smart component are completed in the simulation environment. Secondly, the trajectory planning of robot loading and unloading workstation is made and introduced Finally, the track tracking simulation of the loading and unloading workstation and the production simulation of the whole production line are carried out. The simulation results show that the production line trajectory planning and continuous production reliability have achieved the expected purpose. This scheme can not only provide theoretical basis for the planning, layout and R & D of multi machine tool and multi robot production line, but also provide a verification platform for the optimization of production process and the improvement of production efficiency.