Abstract: MES technology is an important means for enterprises to develop information and intelligence. Aiming at the problems of low information level and complex production process of an automobile factory's three electric integration electric drive assembly line, combining with MES technology, the key technology of process flow is designed and analyzed, and an efficient and feasible process design scheme are put forward. By using VMware virtualization technology, the hardware architecture of the system is improved. On this basis, the process template and production process are optimized. Through the MES platform, the function of process data collection and equipment analysis are realized, the original monitoring mode is improved, OEE is used as the measurement index to quickly find out the production bottleneck, optimize the production process and production structure, and improve the level of production line information and intelligence.