Abstract: Aiming at the low automation, inaccurate output of cutting fluid flow and compressed gas pressure of minimal quantity lubrication device, a micro-lubrication control system based on intelligent algorithm is designed. The hardware part of the system adopted the main controller as STM32F103ZET6 chip. The flow sensor and air pressure sensor realized the real-time detection of parameters. Additionally, the control and execution module of parameters was realized by peristaltic pump and air pressure control valve. Then the software part of the system used keil MDK as the development environment to achieve fuzzy-PID control and man-machine interactive LCD touch screen design. In fact, small overshoot and precise control of the parameters can be presented in fuzzy-PID control algorithm. Finally, the control system realizes intelligent and precise control, and has high stability. The system has engineering application value because of its good human-computer interaction function and high efficiency and precise control of system output parameters.