Abstract: In order to improve the intelligent manufacturing level of the hub die casting production line and die casting island, and to solve the requirements of multi size, high efficiency and high quality in the production process of wheel-hub die casting, a kind of wheel-hub die casting handling robot was designed by using virtual prototype technology. The coordinate system of the handling robot is established using the theory of D-H parameter modeling method, and the forward and reverse kinematics are analyzed. Analyze the working space of the handling robot based on the Monte Carlo method through the Robotics Toolbox of MATLAB. The joint space trajectory planning of the transport robot is carried out by using the quintic polynomial interpolation method, and the angular displacement, angular velocity and angular acceleration of each joint are obtained. The simulation results show that the designed robot is reasonable in structure and can realize the required functions, which provides necessary theoretical reference for the layout of the next prototype production line and the joint planning of process parameters.