Abstract: Aiming at the problems of low work efficiency and low degree of automation in locking screw assembly in industrial automation production, For the automation needs of screws and screw plates auto-locking loading and unloading, automatic locking screw assembly, and so on, A robotic auto-locking screw assembly system was designed, the components and working principle of the system were introduced,the realization path of the automatic locking screw assembly task was planned.The hardware and software of the controller of the robotic auto-locking screw assembly system were designed and the I/O address configuration was made, the robotic auto-locking screw assembly control program was Wrote, the goal of robot auto-locking screw assembly was achieved. Finally, the number of automatic locking screw assemblies through continuous experimental testing was counted. the work efficiency was Analyzed, and the feasibility of robot automatic locking screw assembly was verified. the engineering has a certain value.