Abstract: In view of the characteristics of aviation fastener hexagonal screw fuse hole (mostly nickel cobalt titanium material) which is easy to wear, easy to break, high processing cost and low efficiency. The high-speed EDM numerical control small hole machine tool is selected for improvement. Based on Mitsubishi FX3U series PLC, the automatic feeding and unloading clamping and indexing device for the hexagonal screw fuse hole of aviation fasteners is designed and developed. It has the functions of automatic feeding and unloading, automatic clamping and indexing according to requirements in the processing of hexagonal screw fuse hole, solves the problem that the hexagonal screw fuse hole is difficult to process, and greatly improves the production efficiency.