Abstract: Five-axis turning-milling compound machine tool with dual-drive spindle has the ability to complete all machining procedures by clamping at one time. The lack of supporting software and hardware conditions limits the function of the machine tool. The efficiency of compound motion transformation is improved by adding flexible fixtures interface, and the rapid turning-milling compound NC programming can be realized by special post-processing based on general software development. On the basis of collecting the real-time running data of the machine tool, the intelligent control algorithm can realize adaptive machining to a certain extent, and achieve the purpose of improving the intelligent application level of turn-milling compound machine tool in aero-engine field.