Abstract: In order to study the temperature field distribution in the process of cutting Nitinol cardiovascular stent by fiber laser, a three-dimensional simulation model of Nitinol cardiovascular stent was established by ANSYS finite element software, and the Gaussian heat source was moved along the trail by APDL programming language. The influence of laser power and cutting speed on temperature distribution and variation of different cutting trails was investigated by single factor variable method. The results show that the temperature field distribution of Nitinol tube is almost oval, and the isotherm distribution is dense near the center of heat source, and sparse away from the center of heat source. The cutting area temperature increases with the increase of laser power and decreases with the increase of cutting speed. If the laser power is too high or the cutting speed is too low, the dross will accumulate seriously on the inner surface of the Nitinol tube. When the laser power is too low or the cutting speed is too high, the heat transferred to the tube wall is insufficient, and the workpiece is difficult to cut through. The simulation results can be used to select the actual cutting parameters.