Abstract: Considering the current domestic and foreign market demand for high-speed, high-precision, high automation and high reliability vertical machining center, a certain model of vertical machining center is selected as the test prototype, matched with the domestic Guangzhou CNC intelligent system, and its whole is taken as the research object. The linear axis accuracy and circular arc accuracy of the test prototype are tested by Renishaw laser interferometer and ball bar instrument, and then the reliability of the accuracy of the vertical machining center using the system is verified. The research results show that after compensation and optimization, the accuracy of the machine tool has been significantly improved, and all indicators have reached the internal control standard, which is far lower than the national standard. The research conclusion has certain reference value for the application of the system in the field of machine tools.