Abstract: As a brittle material, glass is prone to crack and edge collapse during grinding. This paper takes quartz glass and glass-ceramics as the research objects, carries out the multi-factor experiment of ultrasonic/non-ultrasonic grinding, analyzes the primary and secondary order of the factors affecting the grinding force and surface roughness and the optimal processing parameters, and studies the influence of the processing methods, parameters and material differences on the grinding force and surface roughness of the two kinds of glass. The results show that the grinding force and roughness of quartz glass and glass-ceramics basically decrease with the increase of spindle speed, increase with the increase of grinding depth, and increase with the increase of feed speed; Compared with quartz glass, the grinding force and surface roughness of glass-ceramics are larger under the same processing parameters and processing methods; Compared with non-ultrasonic working conditions, ultrasonic can significantly reduce the grinding force of two kinds of glass and play a certain role in reducing the surface roughness; However, ultrasonic machining can restrain the grinding force and reduce the surface roughness of glass-ceramics more obviously. The research can provide data support for efficient processing of glass materials.