Abstract: In order to improve the synchronous control performance of electro-hydraulic proportional position in machine tools, the electro-hydraulic proportional position control platform of hydraulic cylinder was built, the OPC-based “industrial computer +PLC” control mode was proposed, and the active disturbance rejection controller was designed for experimental research. The test results show that compared with the single PLC control mode and PID control algorithm, the system response speed is faster, the tracking accuracy is higher and the position synchronization effect is better by using “industrial computer +PLC” and active disturbance rejection control algorithm.