Abstract: The processing of bottle transporter screw is relatively common in mechanical processing, and there are many processing methods. CNC lathes are usually used to process these parts in conjunction with macro programs. It is difficult to use CNC lathes for screws with large arc and large pitch. Four-axis machining centers are used to process such screws with software programming, and the processing cost is higher. In this paper, the processing optimization of typical bottle transporter screw parts has been taken. The process has be optimized and reformed with five aspects: process flow, machine bed, tooling fixture, tool cutter and macro program. According to the research on processing efficiency, equipment cost, tool consumption, processing quality and programming under different working conditions, the processing method with better economic benefits which ensuring processing quality has been found. The low-cost and high-efficiency CNC machining of bottle transporter screw parts which based on 5-parameter adaptive macro program were realized. The production efficiency was improved by more than 300%, and the processing cost was reduced by more than 85%.