Abstract: In order to analyze the effects of cutting speed, feed rate and depth of cut on chip morphology, cutting force and residual stress during finishing turning of titanium alloy wire by centerless lathe. The simulation software ABAQUS is used to establish a 3D finite element finishing turning model based on the centerless lathe, and the experimental design is compared with the simulation results. In the process of turning titanium alloy, high rotational speed will form shorter C-shaped chips, which is conducive to the separation and fracture of chips. Due to the increase of spindle speed, the friction between workpiece and tool decreases and the cutting force decreases with the increase of spindle speed. As the feed speed increases, the amount of feed per revolution increases, the workpiece removal increases, and as the feed speed increases the cutting force increases, and as the depth of cut increases, the cutting removal increases, so the cutting force cutting depth increases and increases. The process of turning titanium alloy needs to increase the speed to reduce the cutting force, which is conducive to the cutting process. At the same time, the feed rate is small, easy to generate C chips, which is conducive to the turning process.