Abstract: A method of combining experiments and finite element simulation was adopted in this article, which is analyzed the deformation process of titanium duct without expansion and rolling process. Influence of rolling process parameters (rolling torque) and roller angle on the forming process of rolling connections was determined. Multiple groups of parameter experiments such as air dense, pressure resistance, blasting, connection strength, and bending fatigue are carried out. Comparative testing was conducted on the sealing performance of titanium alloy conduit without expansion joints. The optimal titanium ducts without expansion and rolling process parameters are determined, which is providing a theoretical basis for improving the quality and reliability of the catheter joint.