Abstract: TK6926 heavy-duty floor boring and milling machine was taken as the research target, and its static, modal and thermal performances were investigated by combining simulation analysis and experimental test. The three-dimensional solid model of the machine tool was established, and the static stiffness, natural frequency, mode shape, temperature field and thermal deformation of the machine tool were obtained by adding boundary conditions. The experimental systems were set up, and the static, modal and thermal performance parameters of the machine tool were measured and compared with the simulation results. The results show that the simulation error of the static stiffness in three directions of the machine tool is not more than 14%, the simulation error of the first three orders of the natural frequency is not more than 15%, and the simulation errors of the key temperature points and the thermal deformation in three directions are not more than 20%. The paper is of guiding significance for the simulation analysis and experimental testing of static, modal and thermal performance of large machine tools.