Abstract: In order to optimize the angle of the milling cutter and improve the milling quality of aluminum honeycomb core, the simulation model of the milling process of the Al5052 honeycomb core was established based on Abaqus, and its accuracy was verified by experiments. On this basis, the influence of tool geometric angle on honeycomb wall milling quality was explored by the single factor method, and a regression model of the influence of tool geometric angle on honeycomb wall milling deformation was established by using the response surface method, and the optimal combination of tool geometric parameters was obtained and verified by experiments. The results show that the tool angle has a great influence on the deformation of the honeycomb wall, and the order of influence is side edge rake angle > helix angle > end edge back angle > side edge back angle, the optimal parameter combination is side edge rake angle 13°, side edge back angle 8°, helix angle 58°, end edge back angle 15°, verified that the milling quality is 64.3% higher than that of general tools.