Abstract: In the context of modern manufacturing pursuing efficient production, the speed and acceleration indicators of high-end CNC machine tools are crucial. This article focuses on the collaborative optimization of the noise increase of the guide rail protective cover and the vibration problem of the Y-axis guide rail protective cover caused by the improvement of the three-axis fast movement speed and acceleration indicators of a certain type of vertical machining center. By increasing the number of glass glue and anti-collision pads, improving the shape combination of anti-collision pads, and using softer anti-collision pads to enhance the buffering effect, the noise has been significantly improved. By using Abaqus finite element analysis, the thickness of the reinforcing ribs inside the original guide rail protective cover bracket was increased from 3 mm to 4mm, and the height was increased from 40 mm to 50 mm. The vibration problem of the Y-axis guide rail protective cover was solved. The final geometric accuracy re-inspection and NAS (national aerospace standard) specimen cutting verification were conducted, and the research results showed that the improvement of speed and acceleration indicators had no significant effect on the geometric accuracy indicators. The processing time of NAS specimens was shortened by 20 s, and the efficiency was improved by 10%. The above research results provide important theoretical basis and practical guidance for the high-performance and low-noise operation of this type of vertical machining center product.