Abstract: Taking the processing of aero-engine blades and disk components as the research object, the functional requirements of the machine tool were determined by analyzing the processing needs of typical components such as blisks and blades. On this basis, the overall layout scheme of the machine tool was formulated. Based on the specification performance parameters and the overall scheme of the machine tool, a five-axis linkage high-grade CNC equipment structure was designed, and key components such as the workpiece clamping device, B-axis, and swing electric spindle milling head were elaborately designed and elaborated. Meanwhile, an independently developed five-axis linkage programming and integrated post-processing software based on CAD/CAM/CNC integration was created. The software utilizes a five-axis RTCP interpolation algorithm to plan the machining trajectory, so as to improve the machining accuracy of the workpiece and the contour accuracy of the intake and exhaust edges. Tests have shown that the RTCP accuracy reaches 0.01 mm. The machining accuracy verification was carried out on the rough and finish machining of a certain aero-engine blade. The results show that the profile contour accuracy of the blade after finish machining is −0.0233/ +0.0158 mm, which meets or even exceeds the level of similar international products.