Abstract: Compressors operating under extreme conditions are taken as the application object. A comprehensive architecture of an intelligent integrated manufacturing system for compressors is constructed based on the principle of full-domain collaboration, focusing on key collaborative behaviors such as process operation flow, material movement, mechanical mechanism motion, control logic, and data interaction. The system, which is characterized by a high degree of production automation, digitalization, networking, and intelligence, has the properties of self-perception, self-adaptation, self-organization, and self-decision-making. It generates collaborative scheduling decision-making instructions through algorithm models to enhance the synchronous collaboration of people, machines, and materials in the whole process and all scenarios. This system meets the requirements of multi-variety, variable-batch, and mixed-flow customized production for compressors under extreme operating conditions. It takes the optimized operation process and the highly integrated intelligent software system as the core to realize the low-cost, high-efficiency, high-quality, and green-low-carbon production of compressors. The international competitiveness of domestic compressors is thus enhanced. The intelligent integrated manufacturing system proposed in this paper mainly consists of four hierarchical domains, namely the intelligence domain, the collaboration domain, the execution domain, and the communication-control domain. The construction methods and functions of each domain are elaborated in detail. The application effect of the system is verified through a practical case. The system architecture of the compressor intelligent integrated manufacturing system presented in this paper provides a valuable reference for intelligent manufacturing practices in other industrial fields.