Abstract: Aiming at the problem that the accuracy of surface quality is limited and the process flow is complex when the existing rigid processing method is used to improve the large-size titanium alloy round hole (diameter is greater than 100 mm), the centrifugal grinding and polishing processing method by the flexible wheel is proposed. Firstly, a three-dimensional numerical simulation model of single abrasive grain, grinding titanium alloy, is established to explore the variation law of temperature field and grinding force in grinding area under different spindle speeds, and the research of the grinding mechanism and the process parameter optimization of titanium alloy are carried out. Secondly, the effects of different flexible wheel materials on the surface roughness, morphology and pore size of the circular hole are investigated, and the relationship between process parameters and surface roughness is analyzed. Finally, the surface quality control method of titanium alloy circular hole by the flexible centrifugal grinding and polishing is proposed. The results show that the grinding temperature is concentrated in the deformation zone. When the rotational speed increases by 1.39 times, the grinding temperature increases by 2.1 times, but the grinding force is less affected by the rotational speed. As the mesh of the abrasive belt wheel is doubled, the surface roughness is reduced by 28%, reaching 0.48 μm. The softer cotton wheel can significantly reduce the surface roughness by 40% and the surface scratches are more delicate. This study verifies the process feasibility of flexible wheel grinding and polishing for titanium alloy materials, and provides an effective way to improve the surface quality of large aperture.