Abstract: Orthogonal tests were conducted to investigate the effects of milling parameters on milling forces during high-strength steel milling with unequal-pitch cutters. Range analysis was used to determine the influence degree of each parameter on milling forces. An empirical formula for milling forces was established, and the model's significance was verified via regression analysis. Results indicate the order of parameter influence on milling forces is a_e>f_z>v_c. Multi-objective particle swarm optimization (MOPSO) was applied for optimization targeting minimum milling force and maximum material removal rate (MRR), yielding 20 sets of balanced milling parameters that balance both objectives, and optimal parameters for unequal-pitch milling that enhance machining efficiency and reduce energy consumption can be provided for reference.