Abstract: In order to address the challenge of coordinated regulation between external spray cooling lubrication and time-varying tool positions, a multi-degree-of-freedom nozzle position and orientation control mechanism integrat with CNC machine tool systems was designed. A method is proposed to dynamically adjust the nozzle position and orientation based on tool position variations. By parsing the NC program to obtain real-time tool position information and combining this with the programming of the PMC, the Y signal of the CNC machine tool is output to an external PLC, thereby achieving optimal nozzle position and orientation regulation for the cutting zone during the machining process. This method requires no host computer, has fast response speed, and eliminates the need for external sensors. On this basis, the effectiveness of the system integration is tested using minimum quantity lubrication (MQL) milling of typical structural components made of GH4169 superalloy. The results show that, under the single-nozzle condition, fixing the incidence angle reduced the cutting force by up to 11.01% and the surface roughness by up to 9.35%, compared with a non-fixed incidence angle. Under the dual-nozzle condition, fixing the incidence angle reduced the cutting force by up to 6.91% and the surface roughness by up to 5.94%. This verifies the effectiveness of the multi-degree-of-freedom nozzle pose control in ensuring precise delivery of cooling lubricants and enhancing machining performance.