Abstract: As the core component of manufacturing, the reliability of production lines directly impacts product quality and production efficiency. The premise of improving production line reliability lies in the accurate evaluation of its reliability level. Traditional evaluation methods, which primarily rely on single indicators such as mean time between failures (MTBF), are no longer sufficient for accurately assessing the reliability of production lines. Therefore, it is necessary to conduct research on the comprehensive evaluation of generalized reliability for production lines. The structure of production lines and the working states of their components are analyzed to summarize and derive evaluation indicators for generalized reliability. To address the issue of overlapping and redundant indicators, a correlation analysis method is employed to screen the indicators, while the entropy weight method is used to assign weights to them. Finally, a comprehensive evaluation of the generalized reliability of production lines is conducted based on an improved extensible matter-element model, and a case study is provided for illustration.