Abstract: The tribological properties of titanium alloy (Ti6Al4V) against cemented carbide (WC-Co) under dry sliding condition were studied by using Optimal SRV tribotester. The effects of load, temperature and sliding speed on the friction process were studied, and the wear mechanism was analyzed by characterizing the micro-morphology of the wear zone. The results show that the friction coefficient fluctuates violently under all experimental conditions, which indicated that serious stick-slip friction occurs, and the stick-slip phenomenon becomes more intense with the increase of load, temperature and sliding speed. In comparison, the effect of sliding speed on friction coefficient is more significant. Micro-morphology analysis shows that the wear form of titanium alloy is mainly adhesive wear, but accompanied by grooves caused by ploughing effect, while cemented carbide mainly shows a certain degree of adhesive wear because of its high hardness.