Abstract: Based on the DELMIA digital assembly simulation platform, taking the unit assembly of an aircraft engine as the research object, this paper makes a plan for the assembly process and realizes virtual assembly simulation in the DPM module in view of the onerous and error-prone problems of aircraft engine assembly. Through interference and collision detection, the rationality of assembly process design is verified. Taking the assembly simulation of the actual station between the element bodies of the high-pressure compressor and combustion chamber as an example, this paper analyzes the visual matching degree, limb workspace, and posture fatigue susceptibility of installation workers combined with the ergonomic simulation technology to optimize unreasonable process postures. According to the results, verifying the assembly process by using virtual assembly technology can find and solve the problems existing in the assembly process in advance, improve the assembly efficiency, and reduce the R&D cost.