Abstract: Piezoelectric ceramic drivers mostly use high-voltage operational amplifiers to amplify the voltage amplitude and power of the piezoelectric ceramic control voltage, which has high voltage control accuracy and is widely used in driving power supplies. However, due to the limitation of its power dissipation, the output power of the high-voltage op-amp of the piezoelectric ceramic drive power supply is limited and cannot be adjusted flexibly. This article provided a high-voltage and high-current piezoelectric ceramic constant current drive circuit. Based on single-chip control, photoelectric isolation, high-precision digital-to-analog conversion, power amplification, MOSFET constant current amplification, digital closed-loop control, and other technologies, the piezoelectric ceramic constant current high current drive was realized, the output current could reach more than ten amperes, and the output voltage could be up to several hundred or even thousands of volts. At the same time, the charging, discharging current, and voltage control of piezoelectric ceramic was also realized through the closed-loop feedback regulation of current and voltage digital.