Abstract: In order to solve the cam profile design of turret tool holder of automatic lathe suitable for various working conditions, an integrated collaborative design method based on VB is proposed to realize cam profile generation, data output, motion characteristic analysis and simulation. Based on the analysis of the combined motion law of cam mechanism, nine kinds of cam profiles are designed, and the visual interface software engineering is developed. The initial parameters of the cam are adjusted in real time according to the required working conditions, and the rationality of the cam profile is verified combined with the simulation analysis results of the kinematic characteristics of the follower. Practice has proved that the function of software engineering is perfect, the design time and software cost are saved by about 50% compared with the traditional graphic method, and the degree of popularization is high.