Abstract: The problems of tool damage and no effective control means often occur in the production site due to manual setting error of NC tool compensation parameters. In view of the above problem, one programmable poka-yoke method of tool compensation parameters manual setting for Siemens NC systems is presented, and a kind of universal poka-yoke NC program for tool compensation parameters setting is also developed. Finally the program is verified in the production site. It is proved that the method is simple and easy to use, cost-effective. The automatic poka-yoke purpose of tool compensation parameters manual setting is realized.