Abstract: In traditional monolithic architecture, the functions of the manufacturing execution system are coupled to each other. In order to improve the reconfigurable and maintainability of manufacturing execution system, Research on key technologies of microservice based manufacturing execution system is carried out, a multi-layer system architecture based on microservice is established to decouple system processes from business logic. A domain scenario-driven microservice decomposition method is proposed, the correlation between tables is calculated by analyzing the relationship between use cases and data, Girvan-Newman (G-N) algorithm is used to decompose the microservices with maximum modularity. Finally, the manufacturing execution system of a bearing enterprise is taken as an application example, the microservice decomposition scheme of manufacturing execution system with the maximum modularity can be obtained by using case diagram and entity relationship diagram.