Abstract: The original error of the machine tools machining process system seriously affects the machining accuracy of the machine tools, and it is crucial to eliminate the corresponding error effects. First of all, a static load loading test program is proposed to simulate the force condition in the actual machining process of the machine tools, and then based on the test to establish a three-axis CNC machine tools geometry and cutting force integrated error model, with a ball tool three-axis CNC milling as the background, the use of a laser interferometer and the “nine-line method” identification method, to measure and identify the above machine tools integrated error. The machine tools error is measured and recognized by using laser interferometer and the “nine-line method” identification method. Then, according to the multi-body system theory and its secondary coordinate transformation matrix, the spatial error model of the three-axis CNC milling of the ball tool is established, and the comprehensive machine tools error is transformed to the position of the center of the ball tool. Finally, according to the surface shaping principle of the workpiece milled by the ball-end cutter, the surface of the cutter center is established to eliminate the integrated machine tools error, to realize the compensation of the integrated error of geometry and cutting force of the three-axis CNC machine tools.